Involvement of hypothalamic neuropeptide Y in pentazocine induced suppression of food intake in rats

@article{Kotagale2014InvolvementOH,
  title={Involvement of hypothalamic neuropeptide Y in pentazocine induced suppression of food intake in rats},
  author={Nandkishor Ramdas Kotagale and Manoj A Upadhya and Pravin N Hadole and Dadasaheb M Kokare and Brijesh Gulabrao Taksande},
  journal={Neuropeptides},
  year={2014},
  volume={48},
  pages={133-141}
}
The potent orexigenic peptide neuropeptide Y (NPY) has been considered as a possible endogenous ligand for a subpopulation of sigma receptors (SigR). However, their mutual interaction with reference to feeding behavior remains poorly understood. In the present study, we explored the possible interaction between sigma1 receptors (Sig1R) agonist, pentazocine, and NPY on food intake in satiated rats. While pentazocine dose-dependently reduced the food intake, NPY significantly increased it at 2, 4… CONTINUE READING

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