Involvement of hypothalamic histamine H1 receptor in the regulation of feeding rhythm and obesity.

@article{Masaki2004InvolvementOH,
  title={Involvement of hypothalamic histamine H1 receptor in the regulation of feeding rhythm and obesity.},
  author={Takayuki Masaki and Seiichi Chiba and Tohru Yasuda and Hitoshi Noguchi and Tetsuya Kakuma and Takeshi Watanabe and Toshiie Sakata and Hironobu Yoshimatsu},
  journal={Diabetes},
  year={2004},
  volume={53 9},
  pages={2250-60}
}
Histamine H(1) receptors (H(1)-Rs) are found in peripheral tissues and in regions of the hypothalamus that are concerned with regulating body composition. In the present study, we investigated the detailed mechanisms of histamine H(1)-Rs in the development of obesity. Histamine H(1)-R knockout (H1KO) mice gradually developed mature-onset obesity, which was accompanied by hyperphagia and decreased expression of uncoupling protein-1 (UCP-1) mRNA. Both younger nonobese (12-week-old) and older… CONTINUE READING
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