Involvement of hydroperoxide in mitochondria in the induction of apoptosis by the eicosapentaenoic acid.

@article{Koumura2005InvolvementOH,
  title={Involvement of hydroperoxide in mitochondria in the induction of apoptosis by the eicosapentaenoic acid.},
  author={Tomoko Koumura and Chika Nakamura and Yasuhito Nakagawa},
  journal={Free radical research},
  year={2005},
  volume={39 3},
  pages={
          225-35
        }
}
Eicosapentaenoic acid (EPA) induced apoptosis of rat basophilic leukemia cells (RBL2H3 cells), whereas 100 microM linoleic acid (LA) had no significant effect. Cytochrome c was released at 4 h. Apoptosis was detected at 6 h after exposure to EPA and docosahexaenoic acid (DHA), and preceded the activation of caspase-3. Liberation of apoptosis-inducing factor (AIF) from mitochondria and its translocation into the nucleus were observed at 4 h. A broad-specificity caspase inhibitor, z-VAD-fmk… CONTINUE READING
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