Involvement of hydrogen peroxide in the differentiation and apoptosis of preosteoclastic cells exposed to arsenite.

@article{Szymczyk2006InvolvementOH,
  title={Involvement of hydrogen peroxide in the differentiation and apoptosis of preosteoclastic cells exposed to arsenite.},
  author={Krysia H Szymczyk and Bethany A Kerr and Theresa A Freeman and Christopher S. Adams and Marla J. Steinbeck},
  journal={Biochemical pharmacology},
  year={2006},
  volume={72 6},
  pages={761-9}
}
Long-term exposure to sodium arsenite (AsO(2)) promotes the development of various cancers. Paradoxically, arsenic also induces pro-myelomonocytic leukemia cell differentiation, and at higher concentrations, apoptosis. The present study investigated the effects of AsO(2) on preosteoclasts. When treated with 2.5-5microM AsO(2), RAW264.7 cells underwent… CONTINUE READING