Involvement of human heat shock protein 90 alpha in nicotine-induced apoptosis.

@article{Wu2002InvolvementOH,
  title={Involvement of human heat shock protein 90 alpha in nicotine-induced apoptosis.},
  author={Yu-ping Wu and Kazuko Kita and Nobuo N. Suzuki},
  journal={International journal of cancer},
  year={2002},
  volume={100 1},
  pages={37-42}
}
There have been conflicting reports of the apoptotic effects of nicotine on human cells and those studies reporting nicotine-induced apoptosis have not unequivocally clarified the molecular mechanisms underlying the effect. However, we found here that human RSa cells, established from embryonic fibroblastic cells doubly infected with Rous sarcoma virus and Simian virus 40, underwent apoptosis when cultured with medium containing 0.06-0.6 microM nicotine. The apoptosis was assessed by cellular… CONTINUE READING

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