Involvement of histone methyltransferase GLP in HIV-1 latency through catalysis of H3K9 dimethylation.

@article{Ding2013InvolvementOH,
  title={Involvement of histone methyltransferase GLP in HIV-1 latency through catalysis of H3K9 dimethylation.},
  author={D Ding and Xiying Qu and Lin Li and Xin Zhou and Sijie Liu and Shiguan Lin and Pengfei Wang and Shaohui Liu and Chuijin Kong and Xiaohui Wang and Lin Liu and Huanzhang Zhu},
  journal={Virology},
  year={2013},
  volume={440 2},
  pages={182-9}
}
Understanding the mechanism of HIV-1 latency is crucial to eradication of the viral reservoir in HIV-1-infected individuals. However, the role of histone methyltransferase (HMT) G9a-like protein (GLP) in HIV-1 latency is still unclear. In the present work, we established four clonal cell lines containing HIV-1 vector. We found that the integration sites of most clonal cell lines favored active gene regions. However, we also observed hypomethylation of CpG of HIV 5'LTR in all four clonal cell… CONTINUE READING