Involvement of histone acetylation in ovarian steroid-induced decidualization of human endometrial stromal cells.

@article{Sakai2003InvolvementOH,
  title={Involvement of histone acetylation in ovarian steroid-induced decidualization of human endometrial stromal cells.},
  author={Nozomi Sakai and Tetsuo Maruyama and Rei Sakurai and Hirotaka Masuda and Yurie Yamamoto and Aki Shimizu and Ikuko Kishi and Hironori Asada and Satoshi Yamagoe and Yasunori Yoshimura},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 19},
  pages={16675-82}
}
Histone acetyltransferases and histone deacetylases (HDACs) determine the acetylation status of histones, regulating gene transcription. Decidualization is the progestin-induced differentiation of estrogen-primed endometrial stromal cells (ESCs), which is crucial for implantation and maintenance of pregnancy. We here show that trichostatin A (TSA), a specific HDAC inhibitor, enhances the up-regulation of decidualization markers such as insulin-like growth factor binding protein-1 (IGFBP-1) and… CONTINUE READING
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