Involvement of heme components in sterol metabolism ofSaccharomyces cerevisiae

@article{Lorenz2006InvolvementOH,
  title={Involvement of heme components in sterol metabolism ofSaccharomyces cerevisiae},
  author={R. Lorenz and L. Parks},
  journal={Lipids},
  year={2006},
  volume={26},
  pages={598-603}
}
  • R. Lorenz, L. Parks
  • Published 2006
  • Chemistry, Medicine
  • Lipids
  • There is an intimate association between sterol biosynthesis in yeast and aerobicity. Besides the requirement for molecular oxygen for the epoxidation of squalene, cytochrome hemoproteins are involved in demethylation and desaturation steps. Regulatory effects of hemes on sterol formation have been demonstrated using specifically defective mutants of yeast. Heme competency participates in a mechanism whereby wild-type cells are prevented from taking exogenous sterols from the growth media. The… CONTINUE READING
    46 Citations

    Figures and Topics from this paper

    Explore Further: Topics Discussed in This Paper

    Squalene-Tetrahymanol Cyclase Expression Enables Sterol-Independent Growth of Saccharomyces cerevisiae
    • 1
    • PDF
    Saccharomyces cerevisiae, a model to study sterol uptake and transport in eukaryotes.
    • 17
    • PDF
    ERGOSTEROL BIOSYNTHESIS: A FUNGAL PATHWAY FOR LIFE ON LAND?
    • 110
    SREBP Pathway Responds to Sterols and Functions as an Oxygen Sensor in Fission Yeast
    • 272
    • PDF
    Role of Heme in the Antifungal Activity of the Azaoxoaporphine Alkaloid Sampangine
    • 34
    • PDF
    Functional characterization of squalene epoxidase genes in the medicinal plant Tripterygium wilfordii.
    • 6

    References

    SHOWING 1-10 OF 57 REFERENCES
    Location and regulation of early enzymes of sterol biosynthesis in yeast.
    • 69
    Inhibition of sterol biosynthesis by ergosterol and cholesterol in Saccharomyces cerevisiae.
    • 22
    Regulation of sterol biosynthesis in yeast: induction of 3-hydroxy-3-methylglutaryl-CoA reductase by glucose.
    • 17
    Sterols in yeast subcellular fractions
    • 10
    A requirement for ergosterol to permit growth of yeast sterol auxotrophs on cholestanol.
    • 81
    Regulation of early enzymes of ergosterol biosynthesis in Saccharomyces cerevisiae.
    • 105
    • PDF