Involvement of heat shock protein 90 in the degradation of mutant insulin receptors by the proteasome.

@article{Imamura1998InvolvementOH,
  title={Involvement of heat shock protein 90 in the degradation of mutant insulin receptors by the proteasome.},
  author={Tomohiko Imamura and Tetsuro Haruta and Yasunori Takata and Isao Usui and Masahiro Iwata and Hajime Ishihara and Manabu Ishiki and Osamu Ishibashi and Eriko Ueno and Toshiyasu Sasaoka and Masashi Kobayashi},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 18},
  pages={
          11183-8
        }
}
We previously reported three families with type A insulin-resistant syndrome who had mutations, either Asp1179 or Leu1193, in the kinase domain of the insulin receptor. The extreme insulin resistance of these patients was found to be caused by the decreased number of insulin receptors on the cell surface, due to the intracellular rapid degradation (Imamura, T., Takata, Y., Sasaoka, T., Takada, Y., Morioka, H., Haruta, T., Sawa, T., Iwanishi, M., Yang, G. H., Suzuki, Y., Hamada, J., and… CONTINUE READING
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