Involvement of heat shock factor in regulating transcriptional activation of MDR1 gene in multidrug-resistant cells.

@article{Kim1997InvolvementOH,
  title={Involvement of heat shock factor in regulating transcriptional activation of MDR1 gene in multidrug-resistant cells.},
  author={S Kim and Wonhee Hur and Chi Dug Kang and Yun Sook Lim and Dong Sung Kim and Byung Seon Chung},
  journal={Cancer letters},
  year={1997},
  volume={115 1},
  pages={9-14}
}
The present study provides evidence that heat shock factor (HSF) may be involved in a transacting factor modulating multidrug resistance 1 (MDR1) gene. In conjunction with the presence of several heat shock elements (HSEs) in the 5' region of the MDR1 gene, we compared the level of HSF which binds to HSEs in multidrug-resistant P388/M and FM3A/M cells with… CONTINUE READING