Involvement of granulocyte-macrophage colony-stimulating factor in pulmonary homeostasis.

  title={Involvement of granulocyte-macrophage colony-stimulating factor in pulmonary homeostasis.},
  author={Glenn Dranoff and A D Crawford and Michel Sadelain and Beverly Ream and Ayesha Rashid and Roderick Terry Bronson and G. Richard Dickersin and Cindy J. Bachurski and Earl Mark and Jeffrey A. Whitsett},
  volume={264 5159},
The in vivo function of murine granulocyte-macrophage colony-stimulating factor (GM-CSF) was investigated in mice, carrying a null allele of the GM-CSF gene, that were generated by gene targeting techniques in embryonic stem cells. Although steady-state hematopoiesis was unimpaired in homozygous mutant animals, all animals developed the progressive accumulation of surfactant lipids and proteins in the alveolar space, the defining characteristic of the idiopathic human disorder pulmonary… CONTINUE READING


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