Involvement of glypican-1 autoprocessing in scrapie infection.

  title={Involvement of glypican-1 autoprocessing in scrapie infection.},
  author={Kajsa L{\"o}fgren and Fang Cheng and L. Fransson and Katarina Bedecs and Katrin Mani},
  journal={The European journal of neuroscience},
  volume={28 5},
The copper-binding cellular prion protein (PrP(C)) and the heparan sulphate (HS)-containing proteoglycan glypican-1 (Gpc-1) can both be attached to lipid rafts via their glycosylphosphatidylinositol anchors, and copper ions stimulate their cointernalization from the cell surface to endosomes. The prion protein controls cointernalization and delivers copper necessary for S-nitrosylation of conserved cysteines in the Gpc-1 core protein. Later, during recycling through endosomal compartments… CONTINUE READING