Involvement of glutathione as a mechanism of indirect protection against spontaneous ex vivo apoptosis associated with bovine leukemia virus.

@article{Alcaraz2004InvolvementOG,
  title={Involvement of glutathione as a mechanism of indirect protection against spontaneous ex vivo apoptosis associated with bovine leukemia virus.},
  author={Teresa Sanchez Alcaraz and Pierre Kerkhofs and M Reichert and Richard Kettmann and Luc Willems},
  journal={Journal of virology},
  year={2004},
  volume={78 12},
  pages={6180-9}
}
Viruses have developed strategies to counteract the apoptotic response of the infected host cells. Modulation of apoptosis is also thought to be a major component of viral persistence and progression to leukemia induced by retroviruses like human T-lymphotropic virus type 1 (HTLV-1) and bovine leukemia virus (BLV). Here, we analyzed the mechanism of ex vivo apoptosis occurring after isolation of peripheral blood mononuclear cells from BLV-infected sheep. We show that spontaneous apoptosis of… CONTINUE READING