Involvement of glucokinase translocation in the mechanism by which resorcinol inhibits glycolysis in hepatocytes.

@article{Agius1997InvolvementOG,
  title={Involvement of glucokinase translocation in the mechanism by which resorcinol inhibits glycolysis in hepatocytes.},
  author={Loranne Agius},
  journal={The Biochemical journal},
  year={1997},
  volume={325 ( Pt 3)},
  pages={
          667-73
        }
}
  • L. Agius
  • Published 1 August 1997
  • Biology, Chemistry, Computer Science
  • The Biochemical journal
Proglycosyn and resorcinol stimulate glycogen synthesis and inhibit glycolysis in hepatocytes. The former effect is attributed to inactivation of phosphorylase mediated by glucuronidated metabolites. This study investigated the mechanism by which resorcinol inhibits glycolysis. Resorcinol (150 microM) inhibited glycolysis in hepatocytes incubated with glucose (15-35 mM) but not with dihydroxyacetone (10 mM). The inhibition of glycolysis at elevated glucose concentration was associated with… 

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