Involvement of genes required for synaptic function in aging control in C. elegans

@article{Shen2007InvolvementOG,
  title={Involvement of genes required for synaptic function in aging control in C. elegans},
  author={Lu-lu Shen and Yang Wang and Da-Yong Wang},
  journal={Neuroscience Bulletin},
  year={2007},
  volume={23},
  pages={21-29}
}
ObjectiveTo identify new genes required for neurosecretory control of aging in C. elegans.MethodsIn view of the importance of nervous system in aging regulation, we performed the screen for genes involved in the aging regulation from genetic loci encoding synaptic proteins by lifespan assay and accumulation of lipofuscin autofluorescence. We further investigated the dauer formation phenotypes of their corresponding mutants and whether they were possibly up-regulated by the insulin-like… Expand
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