Involvement of gag- and env-specific cytotoxic T lymphocytes in protective immunity to feline immunodeficiency virus.

@article{Flynn1995InvolvementOG,
  title={Involvement of gag- and env-specific cytotoxic T lymphocytes in protective immunity to feline immunodeficiency virus.},
  author={Jennifer N. Flynn and Julia A Beatty and Celia A Cannon and Edward B. Stephens and Margaret J. Hosie and James C Neil and Oswald Jarrett},
  journal={AIDS research and human retroviruses},
  year={1995},
  volume={11 9},
  pages={1107-13}
}
Definition of the immunological mechanisms involved in protective immunity against lentiviral infections is crucial to the development of an effective vaccine. The induction of gag- and env-specific cell-mediated immune responses was studied in cats following vaccination with whole inactivated feline immunodeficiency virus (FIV). Cats were immunized by inoculation with three doses of paraformaldehyde-inactivated FIV, derived from the feline lymphoid cell line, FL-4, which is persistently… CONTINUE READING

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