Involvement of free radicals in dementia of the Alzheimer type: a hypothesis.

@article{Volicer1990InvolvementOF,
  title={Involvement of free radicals in dementia of the Alzheimer type: a hypothesis.},
  author={Ladislav Volicer and Peter B. Crino},
  journal={Neurobiology of aging},
  year={1990},
  volume={11 5},
  pages={567-71}
}
We propose that increased formation of oxygen-derived free radicals, such as the superoxide and hydroxyl species, may be responsible for progressive neural degeneration in dementia of the Alzheimer type (DAT). Several processes increase free radical formation and some of them (e.g., brain trauma, aging) are risk factors for DAT. There is some evidence for… CONTINUE READING