Involvement of extracellular and intracellular calcium sources in TRH-induced alpha-MSH secretion from frog melanotrope cells.

@article{Galas1998InvolvementOE,
  title={Involvement of extracellular and intracellular calcium sources in TRH-induced alpha-MSH secretion from frog melanotrope cells.},
  author={Ludovic Galas and Marek Lamacz and Marianne Garnier and Eric W. Roubos and Marie Christine Tonon and Hubert Vaudry},
  journal={Molecular and cellular endocrinology},
  year={1998},
  volume={138 1-2},
  pages={25-39}
}
The stimulatory effect of thyrotropin-releasing hormone (TRH) on alpha-melanocyte stimulating hormone (MSH) secretion from the frog pars intermedia is mediated through the phospholipase C (PLC) pathway but requires extracellular Ca2+. The aim of the present study was to investigate the respective contribution of extracellular and intracellular Ca2+ in the action of TRH on cytosolic calcium concentration ([Ca2+]i) and alpha-MSH release. In normal conditions, TRH (10(-7) M; 5 s) evoked two types… CONTINUE READING