Involvement of estrogen receptor beta in ovarian carcinogenesis.

  title={Involvement of estrogen receptor beta in ovarian carcinogenesis.},
  author={Aur{\'e}lie Bardin and Pascale Hoffmann and Nathalie Boulle and Dionyssios Katsaros and Françoise Vignon and Pascal Pujol and Gwendal Lazennec},
  journal={Cancer research},
  volume={64 16},
Knockout and expression studies suggest that estrogen receptor beta (ERbeta) plays a prominent role in ovarian function and pathology. Moreover, ovarian cancers are characterized by high morbidity and low responsiveness to anti-estrogens. Here we demonstrate, using quantitative PCR to measure ERalpha and ERbeta levels in 58 ovarian cancer patients, that ERbeta expression decreased in cysts and ovarian carcinomas as compared with normal ovaries and that this decrease is attributable only to a… CONTINUE READING
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