Involvement of enhanced neurokinin NK3 receptor expression in the severe asthma guinea pig model.

@article{Mukaiyama2004InvolvementOE,
  title={Involvement of enhanced neurokinin NK3 receptor expression in the severe asthma guinea pig model.},
  author={Osamu Mukaiyama and Kiyoshi Morimoto and Emi Nosaka and Sakiko Takahashi and Makoto Yamashita},
  journal={European journal of pharmacology},
  year={2004},
  volume={498 1-3},
  pages={287-94}
}
In this study, we investigated the involvement of neurokinin NK3 receptors in a severe asthma model prepared by administering ovalbumin via inhalation three times to systemically sensitized guinea pigs. [3H]senktide, a neurokinin NK3 receptor ligand, showed significant specific binding to the lungs from the model animals, but not to those from negative control animals. The airway responsiveness to intravenous neurokinin B, a neurokinin NK3 receptor agonist, was increased in the model… CONTINUE READING