Involvement of endoplasmic reticulum stress in the neuronal death induced by transient forebrain ischemia in gerbil.

@article{Oida2008InvolvementOE,
  title={Involvement of endoplasmic reticulum stress in the neuronal death induced by transient forebrain ischemia in gerbil.},
  author={Yasuhisa Oida and Masamitsu Shimazawa and Kazunori Imaizumi and Hideaki Hara},
  journal={Neuroscience},
  year={2008},
  volume={151 1},
  pages={111-9}
}
Endoplasmic reticulum (ER) stress, which is caused by an accumulation of unfolded proteins in the ER lumen, is associated with stroke and with neurodegenerative diseases such as Parkinson's and Alzheimer diseases. We assessed the expression patterns of immunoglobulin heavy chain binding protein (BiP)/glucose-regulated protein (GRP) 78 (an ER-resident molecular chaperone whose expression serves as a good marker of ER-stress), activating transcription factor (ATF)-4, and C/EBP homology protein… CONTINUE READING

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