Involvement of dynorphin and kappa opioid receptor in yohimbine‐induced reinstatement of heroin seeking in rats

@article{Zhou2013InvolvementOD,
  title={Involvement of dynorphin and kappa opioid receptor in yohimbine‐induced reinstatement of heroin seeking in rats},
  author={Yan Zhou and Francesco Leri and Stephanie L. Grella and Jane V. Aldrich and Mary Jeanne Kreek},
  journal={Synapse},
  year={2013},
  volume={67}
}
Although kappa opioid receptor (KOP-r) antagonists are known to reduce reinstatement of cocaine, alcohol and nicotine seeking induced by a variety of stressors, the role of KOP-r in yohimbine-induced reinstatement of heroin seeking has not been investigated. Yohimbine, used as a stressor, increases the hypothalamic-pituitary-adrenal (HPA) hormones, causes anxiety and induces heroin craving in humans. The present experiments were undertaken to assess the effects of yohimbine on reinstatement of… Expand
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TLDR
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