Involvement of dopamine D3 and D4 receptors in the discriminative stimulus properties of cocaine in the rat.

@article{Ukai2005InvolvementOD,
  title={Involvement of dopamine D3 and D4 receptors in the discriminative stimulus properties of cocaine in the rat.},
  author={Makoto Ukai and H Mitsunaga},
  journal={Methods and findings in experimental and clinical pharmacology},
  year={2005},
  volume={27 9},
  pages={645-9}
}
The present study was carried out to determine the involvement of dopamine receptor subtypes D3 and D4, in the discriminative stimulus effects of cocaine in the rats trained to discriminate 10 mg/kg of cocaine from vehicle. The discriminative stimulus effects of cocaine (1-10 mg/kg) were dose-dependent. The dopamine D2 receptor agonist bromocriptine (1.25-20 mg/kg) and the dopamine D3 receptor agonist R(+)-7-OH-DPAT (0.0001-0.3 mg/kg) produced cocaine (10 mg/kg)-like discriminative stimulus… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.

Similar Papers

Loading similar papers…