Involvement of distinct G-proteins, Gpa2 and Ras, in glucose- and intracellular acidification-induced cAMP signalling in the yeast Saccharomyces cerevisiae.

@article{Colombo1998InvolvementOD,
  title={Involvement of distinct G-proteins, Gpa2 and Ras, in glucose- and intracellular acidification-induced cAMP signalling in the yeast Saccharomyces cerevisiae.},
  author={Sara Grilli Colombo and Peinado Ma and L Cauwenberg and Joris Winderickx and Marion Crauwels and Aloys Teunissen and David Nauwelaers and Johannes H. de Winde and M F Gorwa and Didier Colavizza and Johan M Thevelein},
  journal={The EMBO journal},
  year={1998},
  volume={17 12},
  pages={3326-41}
}
Adenylate cyclase activity in Saccharomyces cerevisiae is dependent on Ras proteins. Both addition of glucose to glucose-deprived (derepressed) cells and intracellular acidification trigger an increase in the cAMP level in vivo. We show that intracellular acidification, but not glucose, causes an increase in the GTP/GDP ratio on the Ras proteins independent… CONTINUE READING