Involvement of different ion channels in osteoblasts' and osteocytes' early responses to mechanical strain.

@article{Rawlinson1996InvolvementOD,
  title={Involvement of different ion channels in osteoblasts' and osteocytes' early responses to mechanical strain.},
  author={Simon C. F. Rawlinson and Andrew A. Pitsillides and Lance Edward Lanyon},
  journal={Bone},
  year={1996},
  volume={19 6},
  pages={609-14}
}
The involvement of functional ion channels in previously documented early responses of osteocytes and osteoblasts to mechanical strain in bone tissue was investigated in explants of rat ulnae by the use of ion channel blockers. Gadolinium chloride (a blocker of stretch/shear-sensitive cation channels) elevated basal prostaglandin (PG) E2 and prostacyclin (PGI2) release and osteocyte glucose-6-phosphate dehydrogenase (G6PD) activity, but was associated with a reduction in basal nitric oxide (NO… CONTINUE READING
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