Involvement of decreased glutamate receptor subunit GluR2 expression in lead-induced neuronal cell death.

@article{Ishida2013InvolvementOD,
  title={Involvement of decreased glutamate receptor subunit GluR2 expression in lead-induced neuronal cell death.},
  author={Keishi Ishida and Yaichiro Kotake and Masatsugu Miyara and Kaori Aoki and Seigo Sanoh and Yasunari Kanda and Shigeru Ohta},
  journal={The Journal of toxicological sciences},
  year={2013},
  volume={38 3},
  pages={
          513-21
        }
}
Lead is known to induce neurotoxicity, particularly in young children, and GluR2, an AMPA-type glutamate receptor subunit, plays an important role in neuronal cell survival. Therefore, we hypothesized that altered GluR2 expression plays a role in lead-induced neuronal cell death. To test this idea, we investigated the effect of exposure to 5 and 20 µM lead for 1-9 days on the viability and GluR2 expression of primary-cultured rat cortical neurons. The number of trypan-blue stained cells was… CONTINUE READING
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