Involvement of cytokines in the histopathology of cerebral malaria.

  title={Involvement of cytokines in the histopathology of cerebral malaria.},
  author={Rachanee Udomsangpetch and Songpol Chivapat and Parnpen Viriyavejakul and Mario Riganti and Polrat Wilairatana and E Pongponratin and Sornchai Looareesuwan},
  journal={The American journal of tropical medicine and hygiene},
  volume={57 5},
Histopathologic and immunohistologic studies were performed in two cases of fatal cerebral malaria. On admission, both patients were in unarousable coma with hyperparasitemia. Examination of the tissue sections from various organs showed parasite sequestration in both cases with more extensive area of sequestration in case 1 than in case 2. A panel of monoclonal antibodies against cytokines applied to these tissues clearly detected tumor necrosis factor-alpha (TNF alpha), interferon-gamma (IFN… CONTINUE READING

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