Involvement of cytochrome epoxygenase metabolites in cutaneous postocclusive hyperemia in humans.

@article{Cracowski2013InvolvementOC,
  title={Involvement of cytochrome epoxygenase metabolites in cutaneous postocclusive hyperemia in humans.},
  author={J. L. Cracowski and Florence Gaillard-Bigot and Claire Cracowski and Claire Sors and Matthieu Roustit and Claire Millet},
  journal={Journal of applied physiology},
  year={2013},
  volume={114 2},
  pages={
          245-51
        }
}
Several mediators contribute to postocclusive reactive hyperemia (PORH) of the skin, including sensory nerves and endothelium-derived hyperpolarizing factors. The main objective of our study was to investigate the specific contribution of epoxyeicosatrienoic acids in human skin PORH. Eight healthy volunteers were enrolled in two placebo-controlled experiments. In the first experiment we studied the separate and combined effects of 6.5 mM fluconazole, infused through microdialysis fibers, and… CONTINUE READING

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