Involvement of cytochrome P450 1A2 in the biotransformation of trans-resveratrol in human liver microsomes.

@article{Piver2004InvolvementOC,
  title={Involvement of cytochrome P450 1A2 in the biotransformation of trans-resveratrol in human liver microsomes.},
  author={Bertrand Piver and Maude Fer and Xavier Vitrac and Jean-Michel M{\'e}rillon and Yvonne Dr{\'e}ano and François Berthou and Dani{\`e}le Lucas},
  journal={Biochemical pharmacology},
  year={2004},
  volume={68 4},
  pages={773-82}
}
This study was aimed at identifying the isoform(s) of human liver cytochrome P450 (CYP) involved in the hepatic biotransformation of trans-resveratrol (trans-3,5,4'-trihydroxystilbene). Trans-resveratrol metabolism was found to yield two major metabolites, piceatannol (3,5,3',4'-tetrahydroxystilbene) and another tetrahydroxystilbene named M1. Trans-resveratrol was hydroxylated to give piceatannol and M1 with apparent K(m) of 21 and 31 microM, respectively. Metabolic rates were in the range 14… CONTINUE READING
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