Involvement of cyclooxygenase-2 in serum-induced prostaglandin production by human oral gingival epithelial cells.

@article{Noguchi2001InvolvementOC,
  title={Involvement of cyclooxygenase-2 in serum-induced prostaglandin production by human oral gingival epithelial cells.},
  author={Kazuyuki Noguchi and Miki Shitashige and Hirahito Endo and Hirobumi Kondo and Yukiharu Yotsumoto and Yuichi Izumi and Hiroshi Nitta and Isao Ishikawa},
  journal={Journal of periodontal research},
  year={2001},
  volume={36 2},
  pages={124-30}
}
The purpose of the present study was to investigate the involvement of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) in prostaglandin (PG) production by human oral gingival epithelial (OGE) cells stimulated with proinflammatory cytokines including interleukin(IL)-1alpha, IL-1alpha and tumor necrosis factor alpha (TNFalpha), and serum. Fetal bovine serum (FBS)-stimulated OGE cells produced significant levels of PGE2, whereas IL-1alpha, IL-1beta and TNFalpha could not induce significant… CONTINUE READING

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