Involvement of cyclin-dependent kinase activities in CD437-induced apoptosis.

Abstract

A novel synthetic retinoid, 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437), is a selective ligand of the RARgamma nuclear receptor. We examined the in vitro effects of CD437 and found that CD437 induces S phase arrest within 24 to 48 h, followed by cell death, in the p53-negative Hep3B and the p53-positive HepG2 human hepatoma… (More)

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@article{Hsu1999InvolvementOC, title={Involvement of cyclin-dependent kinase activities in CD437-induced apoptosis.}, author={S. L. Hsu and S C Yin and M. C. Liu and Uwe Reichert and Won-Kyung Ho}, journal={Experimental cell research}, year={1999}, volume={252 2}, pages={332-41} }