Involvement of cyclic GMP-dependent mechanism in the nitrergic relaxation of the bovine oesophageal groove.

@article{Barahona1999InvolvementOC,
  title={Involvement of cyclic GMP-dependent mechanism in the nitrergic relaxation of the bovine oesophageal groove.},
  author={Mar{\'i}a Victoria Barahona and S S{\'a}nchez-Fort{\'u}n and M Dolores San Andr{\'e}s and Casilda Rodr{\'i}guez},
  journal={Journal of autonomic pharmacology},
  year={1999},
  volume={19 1},
  pages={39-47}
}
1. The present study was designed to investigate the mechanisms involved in the relaxations to nitric oxide (NO) of bovine oesophageal groove preparations suspended in organ baths for isometric tension recordings. In preparations treated with guanethidine (10(-5) M) and atropine (10(-7) M) to block adrenergic neurotransmission and muscarinic receptors, respectively, NO released from nitrergic nerves by electrical field stimulation (EFS, 0.5-16 Hz, 1 ms duration, 20 s trains) and exogenously… CONTINUE READING