Involvement of cyclic AMP in the regulations of lymphokine induced glia cell stimulation.

  title={Involvement of cyclic AMP in the regulations of lymphokine induced glia cell stimulation.},
  author={A. Fontana and R. Jost and S. Balsiger and P. Grob and A. Grieder},
  journal={Brain research},
  volume={254 4},
  • A. Fontana, R. Jost, +2 authors A. Grieder
  • Published 1981
  • Biology, Medicine
  • Brain research
  • T and B lymphocytes of human or murine origin were found to secrete a factor which increases the DNA and RNA synthesis of cultured glia cells. This factor, termed glia cell stimulating factor (GSF), is released upon stimulation of such immune cells by mitogen or antigen qualifying it as a lymphokine. In this communication we report on the role of cyclic AMP (cAMP) in regulating the effect of GSF on glia cells. Prostaglandin E1 (PGE1), isoproterenol and theophylline were effective in suppressing… CONTINUE READING
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