Involvement of cocaine- and amphetamine-regulated transcript peptide in the hyperphagic and body weight promoting effects of allopregnanolone in rats.

@article{Nakhate2013InvolvementOC,
  title={Involvement of cocaine- and amphetamine-regulated transcript peptide in the hyperphagic and body weight promoting effects of allopregnanolone in rats.},
  author={Kartik T. Nakhate and Nishikant K. Subhedar and Ashish P Bharne and P S Singru and Dadasaheb M Kokare},
  journal={Brain research},
  year={2013},
  volume={1532},
  pages={44-55}
}
Allopregnanolone (ALLO), a gamma-aminobutyric acid (GABA) type A receptor active neurosteroid, elicits hyperphagic response in rodents. Since GABA-A receptors are present on the peptidergic neurons in the hypothalamus, we were interested in finding out if ALLO and neuropeptide cocaine- and amphetamine-regulated transcript (CART) interact and influence feeding behavior. While subcutaneous ALLO treatment, for a period of 7 days, produced a significant increase in food intake and body weight… CONTINUE READING
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