Involvement of cholesterol depletion from lipid rafts in apoptosis induced by methyl-β-cyclodextrin.

  title={Involvement of cholesterol depletion from lipid rafts in apoptosis induced by methyl-β-cyclodextrin.},
  author={Risako Onodera and Keiichi Motoyama and Ayaka Okamatsu and Taishi Higashi and Ryusho Kariya and Seiji Okada and Hidetoshi Arima},
  journal={International journal of pharmaceutics},
  volume={452 1-2},
Methyl-β-cyclodextrin (M-β-CyD), which is widely used as a lipid rafts disrupting agent, is known to induce cytotoxicity at high concentration. In the present study, we investigated the potential of M-β-CyD as an antitumor drug. M-β-CyD markedly caused apoptotic cell-death in KB cells, a human oral squamous carcinoma cell line, Ihara cells, a highly pigmented human melanoma cell line, and M213 cells, a human cholangiocarcinoma cell line, through cholesterol depletion in cell membranes. The DNA… CONTINUE READING
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