Involvement of caveolin-2 in caveolar biogenesis in MDCK cells.

  title={Involvement of caveolin-2 in caveolar biogenesis in MDCK cells.},
  author={Ulla Lahtinen and Masanori Honsho and Robert G. Parton and Kai Simons and Paul Verkade},
  journal={FEBS letters},
  volume={538 1-3},
Caveolins have been identified as key components of caveolae, specialized cholesterol-enriched raft domains visible as small flask-shaped invaginations of the plasma membrane. In polarized MDCK cells caveolin-1 and -2 are found together on basolateral caveolae whereas the apical membrane, where only caveolin-1 is present, lacks caveolae. Expression of a caveolin mutant prevented the formation of the large caveolin-1/-2 hetero-oligomeric complexes, and led to intracellular retention of caveolin… CONTINUE READING
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