Involvement of caveolin-1 in the Jak-Stat signaling pathway and infectious spleen and kidney necrosis virus infection in mandarin fish (Siniperca chuatsi).

@article{Guo2011InvolvementOC,
  title={Involvement of caveolin-1 in the Jak-Stat signaling pathway and infectious spleen and kidney necrosis virus infection in mandarin fish (Siniperca chuatsi).},
  author={Chang-jun Guo and Xiaobo Yang and Yan-yan Wu and Li-shi Yang and Shu Mi and Zhao-yu Liu and Kun-tong Jia and Yu-xin Huang and Shao-ping Weng and Xiao-qiang Yu and Jianguo He},
  journal={Molecular immunology},
  year={2011},
  volume={48 8},
  pages={992-1000}
}
Caveolae, the major source of caveolin-1 protein, are specialized invaginated microdomains of the plasma membrane that act as organizing centers for signaling molecules in the immune system. In the present study, we report the cloning and characterization of caveolin-1 (mCav-1) from mandarin fish (Siniperca chuatsi) and study on the roles of mCav-1 in the fish Jak-Stat signaling pathway and in virus infection. The cDNA sequence of mCav-1 was 707bp in size, encoding a protein of 181 amino acids… CONTINUE READING

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