Involvement of cathepsin D in chemotherapy-induced cytochrome c release, caspase activation, and cell death.

@article{EmertSedlak2005InvolvementOC,
  title={Involvement of cathepsin D in chemotherapy-induced cytochrome c release, caspase activation, and cell death.},
  author={Lori A Emert-Sedlak and Sanjeev Shangary and Asaf Rabinovitz and Michelle B Miranda and Scott M Delach and Daniel Ezra Johnson},
  journal={Molecular cancer therapeutics},
  year={2005},
  volume={4 5},
  pages={733-42}
}
Treatment of cells with chemotherapy drugs activates the intrinsic mitochondrial pathway of apoptosis and the caspase protease cascade. Recently, the lysosomal protease cathepsin D has been implicated in apoptosis caused by oxidative stress, inhibition of protein kinase C, and stimulation of the TNFR1 and Fas death receptors. However, the role of cathepsin D in chemotherapy-induced cell death has remained largely unexplored. In this report, we show that treatment of U937 leukemia cells with the… CONTINUE READING

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