Involvement of caspase-3 in photoreceptor cell apoptosis induced by in vivo blue light exposure.

PURPOSE To investigate the potential role of caspase-3 in blue light-induced apoptosis in photoreceptor cells. METHODS Cyclic light-raised Sprague-Dawley rats were exposed to 400 to 480 nm light for 6 hours at an irradiance of 0.64 W/m(2). The rats were then kept in darkness for recovery and killed at scheduled time points from 0 hours up to 24 hours… (More)