Involvement of carbonic anhydrases in the ocular hypotensive effect of melatonin analogue 5-MCA-NAT.

@article{Crooke2012InvolvementOC,
  title={Involvement of carbonic anhydrases in the ocular hypotensive effect of melatonin analogue 5-MCA-NAT.},
  author={Almudena Crooke and Fernando Huete-Toral and Alejandro Mart{\'i}nez-{\'A}guila and Alba Mart{\'i}n-Gil and Jes{\'u}s Pintor},
  journal={Journal of pineal research},
  year={2012},
  volume={52 3},
  pages={265-70}
}
We have previously demonstrated that melatonin and its analogue, 5-methoxycarbonylamino-N-acetyltryptamine (5-MCA-NAT), reduce intraocular pressure (IOP) in New Zealand rabbits. More recently, we have shown that 5-MCA-NAT can also regulate ciliary adrenoceptor gene expression. Like adrenoceptors, carbonic anhydrase (CA) enzymes are involved in aqueous humour secretion by the ocular ciliary epithelium. Moreover, CA enzymes have been reported to be regulated by melatonin. Hence, the aim of this… CONTINUE READING