Involvement of carbohydrate antigen sialyl Lewisx in colorectal cancer metastasis

@article{Nakamori1997InvolvementOC,
  title={Involvement of carbohydrate antigen sialyl Lewisx in colorectal cancer metastasis},
  author={Shoji Nakamori and Masao Kameyama and Shingi Imaoka and Hiroshi Furukawa and Osamu Ishikawa and Yo Sasaki and Yuki Izumi and Tatsuro Irimura},
  journal={Diseases of the Colon \& Rectum},
  year={1997},
  volume={40},
  pages={420-431}
}
PURPOSE: Recognition of metastatic tumor cells with distinct biochemical phenotypes predominant in the primary tumors should be useful not only for establishment of new therapeutic approaches but also for identification of highrisk or low-risk patients for relapse. We examined whether carbohydrate antigens, sialyl Lewisx (sLex) and sialyl Lewisa (sLea) are involved in colorectal cancer metastasis. METHODS: Metastatic abilities of human colon cancer cell variants that were selected for their… 
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It is concluded that carbohydrate expression profiles of cancer cells are relevant to the route of tumor cell dissemination, metastatic pattern as well as prognosis of colorectal cancer.
A disaccharide precursor of sialyl Lewis X inhibits metastatic potential of tumor cells.
TLDR
Treatment of cultured human adenocarcinoma cells with micromolar concentrations of the peracetylated disaccharide reduces the expression of sLe(X) and diminishes binding in vitro to selectin-coated dishes, thrombin-activated platelets, and tumor necrosis factor alpha-activated endothelial cells, suggesting that this compound may represent a novel class of chemotherapeutic agents for prevention and treatment of metastatic disease.
Carcinoembryonic antigen carrying SLeX as a new biomarker of more aggressive gastric carcinomas
TLDR
CEA is the major glycoprotein carrying SLex in gastric carcinoma and the conjoint detection of CEA-SLex is associated with aggressive tumor features highlighting its PLA detection as a biomarker of gastric cancer patient prognosis for theranostic applications.
The role of blood group antigens in malignant progression, apoptosis resistance, and metastatic behavior.
TLDR
Initial experimental evidence is described that supports the hypothesis that carbohydrate-lectin interactions trigger an intracellular signaling cascade culminating in alterations of transcriptional control of gene expression that may be responsible for matrix-independent survival and apoptosis resistance of metastatic cancer cells.
P-selectin deficiency attenuates tumor growth and metastasis.
TLDR
It is shown that P-selectin, which normally binds leukocyte ligands, can promote tumor growth and facilitate the metastatic seeding of a mucin-producing carcinoma.
Breast cancer progression and expression of blood group-related tumor-associated antigens.
TLDR
The data suggest that the expression of sialosyl-LeA and LeB antigens in breast cancer may predict metastases to lymph nodes.
α2,3-Sialyltransferase ST3Gal III Modulates Pancreatic Cancer Cell Motility and Adhesion In Vitro and Enhances Its Metastatic Potential In Vivo
TLDR
The overexpression of ST3Gal III in these pancreatic adenocarcinoma cell lines underlines the role of this enzyme and its product in key steps of tumour progression such as adhesion, migration and metastasis formation.
Attachment of Human Colon Cancer Cells to Vascular Endothelium Is Enhanced by N-Acetylglucosaminyltransferase V
TLDR
It is suggested that GnT-V induces sialyl Lewis x expression and leads colon cancer cells to metastasize by enhancing their ability to attach to vascular endothelium in distant organs, such as liver or lung.
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TLDR
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