Involvement of cannabinoids in the cardioprotection induced by lipopolysaccharide

@article{Lagneux2001InvolvementOC,
  title={Involvement of cannabinoids in the cardioprotection induced by lipopolysaccharide},
  author={Caroline Lagneux and Daniel Lamontagne},
  journal={British Journal of Pharmacology},
  year={2001},
  volume={132}
}
We have examined the involvement of the endocannabinoid system in the cardioprotection triggered by lipopolysaccharide (LPS). Rats were treated with saline or LPS (10 μg Kg−1). 24 h later, hearts were excised, retrogradely perfused, submitted to a low‐flow ischaemia (0.6 ml min−1) for 90 min and reperfused for 60 min. Some hearts were perfused with either SR 141716A (a cannabinoid CB1, receptor antagonist 1 μM), SR 144528 (a CB2 receptor anagonist μM), NNLA (3 μM) or sodium nitroprusside (1 μM… 

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