Involvement of cannabinoid CB1 receptors in the antinociceptive effect of dipyrone

@article{Elmas2013InvolvementOC,
  title={Involvement of cannabinoid CB1 receptors in the antinociceptive effect of dipyrone},
  author={Pınar Elmas and Ahmet Ulugol},
  journal={Journal of Neural Transmission},
  year={2013},
  volume={120},
  pages={1533-1538}
}
Cannabinoid CB1 receptors have been implicated in the antinociceptive effect of paracetamol. In the current study, we examined whether blockade of CB1 receptors prevent the analgesic activity of dipyrone, in a similar way to paracetamol. Hot-plate and tail-flick tests were used to assess the antinociceptive activity in mice. Dipyrone and WIN 55,212-2, a cannabinoid agonist, exerted significant antinociceptive effects in both hot-plate and tail flick tests. The CB1 receptor antagonist, AM-251 (3… Expand
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References

SHOWING 1-10 OF 46 REFERENCES
Evaluation of the endogenous cannabinoid system in mediating the behavioral effects of dipyrone (metamizol) in mice
TLDR
It is reported that thermal antinociceptive, hypothermic, and locomotor suppressive actions of dipyrone are mediated by a noncannabinoid receptor mechanism of action and occurred after acute or repeated administration irrespective of FAAH. Expand
The Additive Antinociceptive Interaction Between WIN 55,212-2, a Cannabinoid Agonist, and Ketorolac
TLDR
An additive antinociceptive interaction between WIN 55,212-2 and ketorolac in an inflammatory visceral pain model is demonstrated, demonstrating the combination of cannabinoids and NSAIDs may have utility in the pharmacotherapy of pain. Expand
The analgesic activity of paracetamol is prevented by the blockade of cannabinoid CB1 receptors.
TLDR
The present results suggest that paracetamol-induced antinociception involves the cannabinoid system, and in rats, two antagonists at cannabinoid CB1 receptors (AM281 and SR141716A) at doses that prevent the analgesic activity of the cannabinoidCB1 agonist HU210 are shown. Expand
A possible central antinociceptive effect of dipyrone in mice.
TLDR
The results suggest that dipyrone may exert a central antinociceptive action reversed by naloxone, and it is suggested that i.t. and i.v. application of the drug produces no significant lesion in the spinal cord. Expand
Endocannabinoid and serotonergic systems are needed for acetaminophen-induced analgesia
TLDR
Acetaminophen‐induced analgesia could involve the following sequence: (1) FAAH‐dependent metabolism of acetaminophen into AM404; (2) indirect involvement of CB1 receptors by this metabolite; (3) endocannabinoid‐dependent reinforcement of the serotonergic bulbospinal pathways, and (4) involvement of spinal pain‐suppressing Serotonergic receptors. Expand
Synergistic anti-allodynic effects of nociceptin/orphanin FQ and cannabinoid systems in neuropathic mice
TLDR
Co-administration of a cannabinoid with a nociceptin/orphanin FQ receptor antagonist resulted in a synergistic interaction, which may have utility in the pharmacological treatment of neuropathic pain. Expand
The local antinociceptive effects of paracetamol in neuropathic pain are mediated by cannabinoid receptors.
TLDR
Paracetamol dose-dependently decreased mechanical allodynia and lowered nociceptive scores associated with hyperalgesia testing and the participation of the peripheral cannabinoid system in paracetaml analgesia is suggested. Expand
The effect of WIN 55,212-2, a cannabinoid agonist, on tactile allodynia in diabetic rats
TLDR
It is suggested that WIN 55,212-2 has an antiallodynic effect in streptozocin-induced diabetic rats and may be a promising approach in the treatment of diabetic neuropathy. Expand
The effect of a paracetamol and morphine combination on dynorphin A levels in the rat brain.
TLDR
All the experimental data suggest that PARA and morphine in combination exert their antinociceptive effect through the opioidergic system, which in turn may cause a decrease in DYN levels in the CNS of the rat. Expand
Involvement of descending serotonergic and noradrenergic pathways in CB1 receptor-mediated antinociception
TLDR
Evidence is provided that systemically administered cannabinoids reinforce the descending serotonergic and noradrenergic pathways to produce acute antinociceptive effects via spinal 5-HT7,5-HT2A and alpha-2 adrenoceptors activation. Expand
...
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3
4
5
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