Involvement of cannabinoid-1 and cannabinoid-2 receptors in septic ileus.

  title={Involvement of cannabinoid-1 and cannabinoid-2 receptors in septic ileus.},
  author={Yongyu Li and Y Li and J-B Ni and C. J. Chen and Sa Lv and S-Y Chai and R Wu and Birol Yuece and Martin Alexander Storr},
  journal={Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society},
  volume={22 3},
BACKGROUND Cannabinoid (CB) receptors are involved in the regulation of gastrointestinal (GI) motility under physiological and pathophysiological conditions. We aimed to characterize the possible influence of CB(1) and CB(2) receptors on motility impairment in a model of septic ileus. METHODS Lipopolysaccharide (LPS) injections were used to mimic pathophysiological features of septic ileus. Spontaneous jejunal myoelectrical activity was measured in rats in vivo, and upper GI transit was… CONTINUE READING
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