Involvement of calmodulin-dependent protein kinases-I and -IV in long-term potentiation.

  title={Involvement of calmodulin-dependent protein kinases-I and -IV in long-term potentiation.},
  author={Michiaki Tokuda and Bushra Y. Ahmed and Yun-fei Lu and Hideki Asoh zToshihiro Matsui and O. Miyamoto and Fumio Yamaguchi and Ryoji Konishi and Osamu Hatase},
  journal={Brain research},
  volume={755 1},
Multifunctional Ca2+/calmodulin-dependent protein kinases (CaMKs) are thought to be involved in the induction of long-term potentiation (LTP). In the present study, LTP was induced by theta burst stimulation in the Schaffer collateral area of the stratum radiatum in the hippocampal CA1 region of the rat hippocampus. LTP-induced and control hippocampal slices were studied by Western blot and immunohistochemical analyses using CaMK-I, -II and -IV antibodies. Increased amounts of all three CaMKs… CONTINUE READING
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