Involvement of calcium channels in the sexual dimorphism of cadmium-induced hepatotoxicity.

@article{Baker2003InvolvementOC,
  title={Involvement of calcium channels in the sexual dimorphism of cadmium-induced hepatotoxicity.},
  author={Thomas K Baker and Heidi B VanVooren and Wendell C. Smith and Mark A Carfagna},
  journal={Toxicology letters},
  year={2003},
  volume={137 3},
  pages={185-92}
}
Cadmium toxicity has been evaluated in a number of in vivo and in vitro toxicological studies. In vivo Cd toxicity exhibits sexual dimorphism with females being more susceptible to Cd uptake, accumulation, and toxicity in the liver. Research to date does not explain why females are more sensitive to Cd-induced hepatotoxicity. Recent studies demonstrate that progesterone sensitizes female F(344) rats and TRL-1215 cells to Cd toxicity, however the mode of action is still unclear. Approximately… CONTINUE READING