Involvement of calcium and G proteins in the acute release of tissue-type plasminogen activator and von Willebrand factor from cultured human endothelial cells.

@article{EijndenSchrauwen1997InvolvementOC,
  title={Involvement of calcium and G proteins in the acute release of tissue-type plasminogen activator and von Willebrand factor from cultured human endothelial cells.},
  author={Y van den Eijnden-Schrauwen and D. E. Atsma and Florea Lupu and Reinout E. de Vries and Teake Kooistra and Jef J. Emeis},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={1997},
  volume={17 10},
  pages={2177-87}
}
In this study, we investigated the role of Ca2+ and G proteins in thrombin-induced acute release (regulated secretion) of tissue-type plasminogen activator (TPA) and von Willebrand factor (vWF), using a previously described system of primary human umbilical vein endothelial cells (HUVECs). The acute release of TPA and vWF, as induced by alpha-thrombin, was almost zero after chelation of Ca2+i, showing that an increase in [Ca2+]i was required. It did not matter whether the increase in [Ca2+]i… CONTINUE READING
34 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 34 extracted citations

Similar Papers

Loading similar papers…