Involvement of c-Src in diperoxovanadate-induced endothelial cell barrier dysfunction.

@article{Shi2000InvolvementOC,
  title={Involvement of c-Src in diperoxovanadate-induced endothelial cell barrier dysfunction.},
  author={Shujie Shi and Joe G. N. Garcia and Shukla Roy and Narasimham L. Parinandi and Viswanathan Natarajan},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2000},
  volume={279 3},
  pages={L441-51}
}
Reactive oxygen species (ROS) generated by activated leukocytes play an important role in the disruption of endothelial cell (EC) integrity, leading to barrier dysfunction and pulmonary edema. Although ROS modulate cell signaling, information remains limited regarding the mechanism(s) of ROS-induced EC barrier dysfunction. We utilized diperoxovanadate (DPV) as a model agent to explore the role of tyrosine phosphorylation in the regulation of EC barrier function. DPV disrupted EC barrier… CONTINUE READING