Involvement of brain cytokines in the neurobehavioral disturbances induced by HIV-1 glycoprotein120.

  title={Involvement of brain cytokines in the neurobehavioral disturbances induced by HIV-1 glycoprotein120.},
  author={Ohr Barak and Inbal Goshen and Tamir Ben-Hur and Joseph Weidenfeld and A. Newman Taylor and Raz Yirmiya},
  journal={Brain research},
  volume={933 2},
Intracerebroventricular (i.c.v.) administration of HIV-1 glycoprotein 120 (gp120), the envelope protein used by the virus to gain access into immune cells, induces neurobehavioral alterations in rats. To examine the role of proinflammatory cytokines in mediating these effects, we measured the effects of gp120 on brain proinflammatory cytokine expression and the effects of anti-inflammatory agents, including interleukin-1 receptor antagonist (IL-1ra), pentoxifylline (a TNFalpha synthesis blocker… CONTINUE READING


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