Involvement of brain cytokines in the neurobehavioral disturbances induced by HIV-1 glycoprotein120.

@article{Barak2002InvolvementOB,
  title={Involvement of brain cytokines in the neurobehavioral disturbances induced by HIV-1 glycoprotein120.},
  author={Ohr Barak and Inbal Goshen and Tamir Ben-Hur and Joseph Weidenfeld and A. Newman Taylor and Raz Yirmiya},
  journal={Brain research},
  year={2002},
  volume={933 2},
  pages={98-108}
}
Intracerebroventricular (i.c.v.) administration of HIV-1 glycoprotein 120 (gp120), the envelope protein used by the virus to gain access into immune cells, induces neurobehavioral alterations in rats. To examine the role of proinflammatory cytokines in mediating these effects, we measured the effects of gp120 on brain proinflammatory cytokine expression and the effects of anti-inflammatory agents, including interleukin-1 receptor antagonist (IL-1ra), pentoxifylline (a TNFalpha synthesis blocker… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 18 references

Interleukin - 1 inhibits Garcia , HIV - and FIV - derived gp 120 alter spatial memory , LTP , and sexual behavior in female but not in male rats

  • J. Criado Sanchez-Alavez, M. Gomez-Chavarin, +4 authors E. Cohen
  • Brain Behav . Immun . sleep in rats , Neurobiol…
  • 2000

In vivo induction of interleukin - 1 of the effect of Mycoplasma fermentans on the hypothalamo – bioactivity in brain tissue after intracerebral infusion of native gp 120 pituitary – adrenal axis

  • M. Emery, E. Lai, +4 authors J. M. Weiss Characterization Kalyanaraman
  • Neuroendocrinology
  • 1997

Tumor sickness - induced decreases in food - motivated behavior , Neurosci . necrosis factor involvement in lipopolysaccharide induced inhibition Biobehav

  • F. Squadrito G. Calapai, D. Altavilla, +7 authors A. Sardella
  • Neurosci . Res . Commun .
  • 1997

Cognitive deficits and emotional disorders in HIV - 1 of the interleukin - 1 receptor antagonist ( IL - 1 ra ) ,

  • G. N. Smagin A. H. Swiergiel, L. J. Johnson, A. J. Dunn
  • Brain Res . 776 infected individuals , Acta…
  • 1995

Biological properties of interleukin 10 , interleukin - 1 in the induction of sickness behavior in mice , Psycho - Immunol

  • S. Suarez, P. Parnet, Q. Pittman, R. Dantzer, A. O’Garra Howard
  • 1992

Synergism between IL - 1 b and TNF - a on the and AIDS dementia complex

  • B. Brew, J. Sidtis, +4 authors G. F. Borm
  • 1988

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