Involvement of both syn- and anti-dihydrodiol-epoxides in the binding of 7, 12-dimethylbenz(a)anthracene to DNA in mouse embryo cell cultures.

@article{Sawicki1983InvolvementOB,
  title={Involvement of both syn- and anti-dihydrodiol-epoxides in the binding of 7, 12-dimethylbenz(a)anthracene to DNA in mouse embryo cell cultures.},
  author={J T Sawicki and Robert C. Moschel and Anthony Dipple},
  journal={Cancer research},
  year={1983},
  volume={43 7},
  pages={3212-8}
}
7,12-Dimethylbenz(a)anthracene (DMBA):deoxyribonucleoside adducts, from enzymic hydrolyses of DNA from mouse embryo cells exposed in culture to [3H]DMBA, can be separated into two fractions on the basis of whether or not they bind to the phenyl boronic acid residues of Servacel DHB. This suggests that these two fractions of adducts are derived from anti and syn bay-region dihydrodiol-epoxides, respectively. The fluorescence spectra and interactions of the major components of these two fractions… CONTINUE READING
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